UNIS was officially founded in 1997 as the successor institution of the Instituto Femenino de Estudios Superiores (IFES), (Institute of Higher Education for Women). The assets and employees of IFES were transferred to the Universidad del Istmo in September 1997, when the university officially received its charter from Guatemala's Consejo de la Enseñanza Privada Superior (Council of Private Higher Education). There are universities in Panama City, Panama and Oaxaca, Mexico by the same name.

School Director: Bishop Fernando Ocáriz Braña

Population: 50000

Population of Teaching Staff:

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